Review: catechol O-methyl transferase inhibitors plus L-dopa and some surgical interventions improve Parkinson disease symptoms.

S t u d y s e l e c t i o n a n d a s s e s s m e n t Studies were selected if they were randomized controlled trials (RCTs) of pharmacologic (dopamine agonists [DAs] plus L-dopa, selegiline plus L-dopa, or catechol O-methyl transferase [COMT] inhibitors plus L-dopa vs L-dopa alone), psychiatric (piracetam or citalopram vs placebo), surgical (pallidotomy, deep brain stimulation [DBS], and fetal cell transplantation), or ancillary (physiotherapy, speech or language therapy, and rehabilitation) interventions; were published in English; and had ≥ 10 patients.